Hello everyone,
I hope you’ll share in my joy, but I apologize for not keeping my blog current. I’ve been deeply engrossed in learning with my vibrant new community. In a previous post, I expressed my excitement about finally connecting with others following the same protocol. However, my relief and support since then have far exceeded my expectations. I’ve learned much and am doing my best to assist others. It’s been a rewarding, albeit daunting, journey, but I am convinced it’s the right path.
Regarding my current treatment (Protocol 6), there’s not much exciting to report. I am continuing with the enteric-coated pills as in the previous round. I have one more dose this Friday, and then I will have two weeks off and will evaluate its effectiveness. I get a PET scan on the 22nd and am super excited!
Lately, there has been a lot of discussion in the group about the method of administration. Most are still comfortable taking the dry powder orally, with many placing it under their tongue as a sublingual. However, when we discuss sublingual or enteric-coated capsules, we are essentially discussing the best of the worst options. Oral is considered the least effective route. One of your wonderful readers commented on sublingual administration many months ago, prompting me to delve deeper into this method. After thorough research, I decided against it. This doesn’t mean I am definitively correct, only that I chose to rule it out based on the following reasoning:
Two main factors influence the effectiveness of sublingual absorption: the molecule’s size and solubility. Other considerations, such as the volume of medication and taste, are less critical. The substance needs to be smaller than 500 Daltons for molecular size to be efficiently absorbed sublingually. Referring to PubChem, the molecular weight of the substance in question (DON) is 171.15 g/mol (171.15 Daltons), which is sufficiently small. Regarding solubility, whether a substance is water or fat-soluble significantly affects absorption. I confirmed through a quick Google search using “6-Diazo-5-oxo-L-norleucine solubility” that numerous sources agree it is water soluble, not fat. This primarily is why I prefer enteric over sublingual methods. Moreover, one of the lead researchers I spoke to supported the logic behind using enteric capsules as being sound during our discussion on optimal oral administration methods. Although we didn’t delve specifically into sublingual options, the context of finding the best oral administration strategy implied it.
Therefore, I will continue using an enteric capsule until I consider trying subcutaneous administration. I won’t switch to subcutaneous unless the upcoming scan fails to show a significant decrease in tumour load. If the results are not satisfactory, I may explore this alternative.
Other changes I’ve made from the beginning include discontinuing psyllium husk, which has made no difference to me. I take an enteric pill 1 to 1.5 hours before HBOT and stay in for 90-120+ minutes. When I go home, I experience no side effects, and you would be surprised at how low my glucose levels are in the tank. Based on traditional medical school teachings, my readings should be alarming. Unfortunately, these programs don’t offer much insight into the body’s metabolic processes or provide any deep dives into cellular biology.
And to stop the disbelievers, let me clarify that yes, my meter works in the hyperbaric tank, and yes, this also happens to others doing this protocol. Also, no, I don’t feel funny when it happens. But I do find it interesting that doctors find it interesting.
